Wound healing

Celluma light therapy is uniquely certified for the treatment of skin wounds

In original research conducted at the renowned Beckman LASER Institute at the University of California, Celluma was clinically proven to accelerate the rate of wound closure and match or exceed cold LASER with similar optical parameters4.

The Celluma is medically CE marked in Europe for all FDA indications, and for dermatological wound healing as a Class 11A medical device in the European Union. LED therapy with the Celluma is ideal for use after surgical procedures to improve the healing of incisions or non-healing wounds. LED therapy with the Celluma can help reduce patient downtime and fight infections while increasing overall patient satisfaction.

Light therapy has been shown to accelerate tissue repair, reduce wound size and accelerate wound closure and other beneficial effects. These mechanisms have been shown to promote dermal wound healing and reduce pain associated with the healing process. The Celluma is intended for dermal wound healing and refers to the treatment of superficial wounds that exist on the outer 2 mm of the skin, including normal, acute postoperative and chronic wound healing, including but not limited to diabetic ulcers

The groundbreaking research for Low Level Light Therapy (LLLT), also known as LED therapy, was conducted by NASA's Marshall Space Flight Center out of concern for astronauts who might become injured or ill during a long-term flight in space. In response to this health risk, NASA developed Light Emitting Diode (LED) technology, which showed promise for delivering light energy deep into the body to promote wound healing and human tissue growth. The therapeutic benefits of LLLT have been demonstrated in thousands of clinical studies, articles and peer-reviewed literature to show that the mechanism of action is cellular absorption of photons (light energy) and increased production of adenosine triphosphate (ATP), the form of energy used by cells to fuel cellular activity. The resulting ATP is then used to power metabolic processes, which include the synthesis of DNA, RNA and the proteins and enzymes needed to repair or regenerate cells.

Low-level light therapy has been shown to reduce a patient's recovery time while reducing discomfort and improving overall outcomes. It is ideal after any ablative procedure and before and after surgery for the following reasons:

• Phototherapy has been shown to accelerate tissue repair, reduce wound size, accelerate resolution of erythema, accelerate wound closure and prevent dehiscence¹.
• Phototherapy before surgery can reduce the incidence of hypertrophic scars and keloids ².
• Ongoing postoperative photorejuvenation² (activation of fibroblasts to produce collagen and elastin, stimulation of keratinocytes that produce keratin to give structural firmness to the skin).
• Prevention of post-inflammatory hyperpigmentation².
• Activation of mast, macrophage and neutrophil cells can reduce inflammation and protect against infection.
• Phototherapy is antibacterial. The presence of P acne bacteria can lead to postoperative infections, especially in shoulder surgery. The use of professional LED light therapy before surgery can reduce the presence of these bacteria.

Studies on wound healing

There are hundreds of studies detailing the benefits of LED light therapy and its positive effects on wound healing including burns, surgical incisions and diabetic ulcers. Below is an excerpt and summary of photobiomodulation therapy for wound care: An effective, non-invasive, phototechnical approach³. Adv Skin Wound Care. (2019) on the Light therapy for wound healing.

General purpose: To provide background information and investigate evidence for the therapeutic use of light energy treatments for wound healing.

Target group: This training activity is aimed at physicians, physician assistants, nurses with an interest in skin and wound care

Abstract: To provide background information and examine evidence for the therapeutic use of light energy treatments for wound healing. PubMed was searched for scientific articles published in the last 5 years using the search terms "photobiomodulation therapy" and "low-level laser therapy", and these terms were combined with "wound" using a "human species" filter. This search returned 218 articles about photobiomodulation therapy or low-level laser therapy and wound. Of these, only articles on in vivo wound care with light treatments were specifically included in this review (n = 11). The wound healing effects of low-dose laser treatments were first described over 50 years ago. Various doses ranging from 0.1 to 10 J/cm and wavelengths from 405 to 1,000 nm appear to offer therapeutic benefits for a wide range of chronic wounds. A range of light energy sources from LEDs to lasers have been used, with specific benefits and limitations. There is a lack of consensus on standardised treatment parameters such as wavelengths, dose and therapeutic outcomes in the studies reviewed, which prevents direct comparison and recommendation of a clinical protocol. Expert opinion is offered based on ongoing research studies and reported literature. Non-invasive, economical and multipurpose light devices are an attractive tool for wound care. However, there is an urgent need in the wound care community to develop optimal clinical protocols for use based on well-designed, rigorous clinical research studies.

In a 2014 study conducted at the University of California Beckman LASER Institute titled Comparison of Laser and Diode Sources for Accelerating In Vitro Wound Healing with Low-Level Light Therapy ⁴, Celluma compared favourably with a low-level laser for wound closure. Here is the abstract:

Low-level light therapy has been shown to improve in vitro wound healing. However, there is a lack of clearly defined parameters of the different light sources for this therapy. The aim of this study was to (1) determine whether the wavelengths tested are effective for in vitro wound healing and (2) compare a laser and a light-emitting diode (LED) source at similar wavelengths. We show that four wavelengths delivered by either a laser or an LED array enhanced in vitro wound healing in A549, U2OS and PtK2 cells. The enhanced wound healing occurred through increased cell migration as demonstrated by scratch wound and transwell assays. Cell proliferation was tested using the (3-(4,5-dimethylthiazol-2-yl)-5-(3-car-boxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) (MTS) assay and was generally not involved in the wound healing process. The laser and LED sources were found to be comparable when equal doses of light were applied. The measured biological response was similar in most cases. We conclude that the laser at 652 (5.57 mW∕cm2, 10.02 J∕cm2) and 806 nm (1.30 mW∕cm2, 2,334 J∕cm2) (full bandwidth 5 nm) and the LED at 637 (5.57 mW∕cm2, 10.02 J∕cm2) and 901 nm (1.30 mW∕cm2, 2.334 J∕cm2) (full bandwidth 17 and 69 nm) induce comparable levels of cell migration and wound closure.

References:

1. the effects of LED emissions on sternotomy incision repair after myocardial revascularisation: a randomised double-blind follow-up study Rauirys Alencar de Oliveira & Gilderlene Alves Fernandes & Andréa Conceição Gomes Lima & Antônio Dib Tajra Filho & Raimundo de Barros Araújo Jr. & Renata Amadei Nicolau Received: 2 August 2013 /Accepted: 25 November 2013 Springer-Verlag London 2013

2. Light-emitting diodes (LEDs) in dermatology. D. Barolet, M.D. 2008.

3. Mosca RC, Ong AA, Albasha O, Bass K, Arany P. Photobiomodulation therapy for wound care: An effective, non-invasive, phototechnical approach. Adv Skin Wound Care. 2019;32(4):157-167. doi:10.1097/01.ASW.0000553600.97572.d2

4. Ryan Spitler a,* and Michael W. Berns a,b Comparison of laser and diode sources for acceleration of in vitro wound healing by low-level light therapy. aUniversity of California Irvine, Beckman Laser Institute, Department of Developmental & Cell Biology, 1002 Health Sciences Road, Irvine, California 92612 bUniversity of California San Diego, La Jolla, California 92093. Journal of Biomedical Optics 19(3), 038001 (March 2014).

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